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The cause of interstitial cystitis remains unknown, despite the proposal of several theories that may explain the pathophysiology of the condition. Contrary to other types of cystitis, there does not appear to be an infection of the bladder and antibiotics do not offer a benefit to patients.
Inflammation that is associated with the bladder is thought to cause the symptoms, although medical experts do not agree upon the origin of this. Ulceration, scarring and stiffness of the bladder may play a role as causative factors of the inflammation.
There are several theories proposed by medical researchers that explain the possible causes of the condition, which are described in more detail below.
Damage to the bladder lining or epithelium may lead to inflammation and irritation of the bladder, resulting in the painful symptoms observed in patients with interstitial cystitis.
This could potentially lead to the leakage of urine from the bladder into the surrounding muscles and nerves. As a result, the pain and other symptoms may affect the entire abdominal area in close proximity to the bladder.
Possible situations that may affect the bladder lining and cause the condition include:
The pelvic floor muscles play an important role in the control of the bladder and urination process. It has been proposed that a problem with the pelvic floor muscles may lead to inflammation of the bladder and act as a cause of interstitial cystitis.
This may result from a dysfunction of the pelvic floor muscles, or weakening of the muscle over time for varying reasons.
Although a genetic link is unlikely to be the sole cause of interstitial cystitis, it may be possible for individuals to inherit a predisposition to the condition.
Some cases have been reported of blood relatives being affected, including cases of a mother and daughter, and sisters being affected. However, to date no specific gene has been linked to an increased risk of the condition.
In some patients, there may be damage to the nerves that are responsible for carry sensory messages from the bladder. This has the potential to cause pain associated with normal physiological events, such as the filling of the bladder.
An autoimmune response involving the destruction of the cells in the bladder has also been proposed as a cause of the condition. It is more common for individuals with an autoimmune disorder to suffer from interstitial cystitis, which suggests autoimmunity may be involved in the pathophysiology.
This theory is linked to several other related health conditions that may play a role in the cause.
Interstitial cystitis has been linked to several other conditions, due to the high frequency of patients that present concurrently with other symptoms and conditions. These include:
This suggests that interstitial cystitis may be a component of a more complex syndrome, involving a broad number of factors and organ systems.
Medical researchers continue to investigate the pathophysiology of interstitial cystitis, as successful treatment options will become clearer when more is known about the cause of the condition. In the future, it is hoped that targeted treatments could help to address the specific cause of the condition.