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Celiac disease involves inflammation and damage caused to the inner lining of the small intestines due to an autoimmune process.
Some of the diseases that need to be ruled out while making a diagnosis of celiac disease include:-
Suggested diagnostic pathway for detecting celiac disease includes:–
The common tests applied are –
Once these abnormalities are detected, an intestinal biopsy is recommended. More than one biopsy is taken from the second or third part of the duodenum. Best samples are obtained with the suction biopsy using a Crosby capsule.
Once the biopsy is mounted on a slide it shows definitive findings under the microscope. The mucosa of the proximal small intestine is affected and the damage shows decreasing intensity towards the distal small intestine.
In more severe cases the damage may extend up to the ileum. In silent cases or asymptomatic cases the damage is mild.