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William Dameshek in 1951 first described the term chronic myeloproliferative disorder. It encompassed four entities that were clinically separate. These included:
It was in 2001 that the World Health Organization added several entities to this list including:
This list was further modified in 2008 by the WHO. The WHO then changed the terminology from “myeloproliferative disease” to “myeloproliferative neoplasm”. In addition they added Mastocytosis to this new category.
The diagnostic criteria were also altered from the 2001 report. The new categories included:
For diagnosis of MPN the criteria include:
Blood examination:
Bone marrow examination:
Cytogenetic analysis: