Bipolar disorder, an illness of in which there are sustained mood swings either up (mania) or down (depression). During mania, patients experience episodes of overactivity, elation or irritability. During depression, patients may feel depressed or guilty, lack energy, lose their appetite and have trouble sleeping.

Recurrent major depressive disorder, an illness where depression is longer lasting and/ or more severe than the "low moods" everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in parts of the brain. This imbalance affects your whole body and can cause emotional and physical symptoms such as feeling low in spirit, loss of interest in activities, being unable to enjoy life, poor appetite or overeating, disturbed sleep, often waking up early, loss of sex drive, lack of energy and feeling guilty over nothing.

Generalised anxiety disorder, where patients have excessive anxiety and worry.

Schizophrenia, an illness with disturbances in thinking, feelings and behaviour

quetiapine, the active ingredient in quetiapine modified release tablets

any of the other ingredients listed at the end of this leaflet.

any other medicines

any other substances such as foods, dyes or preservatives

heart or blood vessel problems or a family history of heart or blood vessel problems including low blood pressure, stroke, problems with your circulation or any condition that affects blood flow to the brain, problems with the way your heart beats or a history of heart attack

liver problems

diabetes or a family history of diabetes. Patients with diabetes or who have a higher chance of diabetes should have their blood sugar checked before and during treatment with quetiapine modified release tablets.

epilepsy (seizures or fits)

dementia or related behavioural disorders (especially in elderly patients)

low white blood cell count

sleep apnea - a condition where you stop breathing for short periods during your normal nightly sleep

urinary retention (a condition where you can't completely empty your bladder)

an enlarged prostate

a blockage in your intestines

increased pressure inside your eyes or glaucoma

phenytoin or carbamazepine -medicines for epilepsy

medicines for high blood pressure (including diuretics or fluid tablets) or heart conditions

lorazepam - a medicine used to help you sleep

medicines used to treat anxiety, depression, mood swings, attention deficit hyperactivity disorder (ADHD) or other mood disorders

medicines for fungal infections such as ketoconazole

some antibiotics such as rifampicin and erythromycin

thioridazine - an antipsychotic medicine

medicines used to treat Parkinson's disease

stimulants such as amphetamines

glucocorticoids - medicines used to treat inflammation

medicines for Human Immunodeficiency Virus (HIV)

medicines that have anticholinergic (muscarinic) effects

thoughts or talk of death or suicide

thoughts or talk of self-harm or harm to others

any recent attempts of self-harm

increase in aggressive behaviour, irritability or agitation

worsening of depression

feeling sleepy

weight gain, increased appetite

dry mouth

upset stomach, constipation, indigestion, vomiting (mainly in elderly or children)

feeling weak

swelling of the hands, ankles or feet

runny or stuffy nose (particularly in children)

blurred vision

abnormal dreams, nightmares

irritability

shortness of breath, difficulty in breathing and/or tightness in the chest

fast or irregular heartbeats (palpitations)

difficulty swallowing

falling, feeling dizzy or faint on standing up

difficulty in speaking

rapid heart beat

symptoms of high sugar levels in the blood (including passing large amounts of urine, excessive thirst, increase in appetite with a loss of weight, feeling tired, drowsy, weak, depressed, irritable and generally unwell)

breast enlargement, unusual secretion of breast milk

abnormal muscle movements, including difficulty starting muscle movements, shaking, restlessness or muscle stiffness without pain.

worm-like movements of the tongue or other uncontrolled movements of the tongue, mouth, cheeks or jaw which may progress to the arms and legs

a sudden increase in body temperature, with sweating, or a fast heart beat

bleeding or bruising more easily than normal

very marked drowsiness

reduced consciousness

fits (seizures)

long-lasting and painful erections

fainting (particularly in children)

severe allergic reaction (may include severe difficulty in breathing, shock, swelling of the face, lips, tongue or other parts of the body, skin rash, hay fever, or you may feel faint)

signs of frequent infections such as fever, chills, sore throat or mouth ulcers

severe upper stomach pain, often with nausea and vomiting (particularly in patients with other risk factors such as gallstones, alcohol consumption and/or increased levels of certain fats within the blood)

50 mg - brown

150 mg - white

200 mg - yellow

300 mg - light yellow

400 mg - white

Other ingredients include:

Microcrystalline cellulose

Sodium citrate anhydrous

Magnesium stearate

Hypromellose

Macrogol 400

Polysorbate 80

Titanium dioxide (E171)

Iron oxide red CI77491 (E172 - 50 mg, 200 mg and 300 mg tablets)

Iron oxide yellow CI77492 (E172 - 50 mg, 200 mg and 300 mg)

Iron oxide black C177499 (50 mg and 300 mg tablets)